Hepatic Fibrosis - Hepatic and Biliary Disorders. Hepatic fibrosis is overly exuberant wound healing in which excessive connective tissue builds up in the liver. The extracellular matrix is overproduced, degraded deficiently, or both. The trigger is chronic injury, especially if there is an inflammatory component. Fibrosis itself causes no symptoms but can lead to portal hypertension (the scarring distorts blood flow through the liver) or cirrhosis (the scarring results in disruption of normal hepatic architecture and liver dysfunction). Diagnosis is based on liver biopsy. Treatment involves correcting the underlying condition when possible. In hepatic fibrosis, excessive connective tissue accumulates in the liver; this tissue represents scarring in response to chronic, repeated liver cell injury. Free ebook: Machiavelli's Laboratory "Ethics taught by an unethical scientist" 12,000 BIOMEDICAL ABBREVIATIONS This page is provided "as is", without warranty of any. It is the most common cause of neonatal hypoglycemia that. Commonly, fibrosis progresses, disrupting hepatic architecture and eventually function, as regenerating hepatocytes attempt to replace and repair damaged tissue. When such disruption is widespread, cirrhosis is diagnosed. Various types of chronic liver injury can cause fibrosis (see Table: Disorders and Drugs That Can Cause Hepatic Fibrosis). Self- limited, acute liver injury (eg, acute viral hepatitis A), even when fulminant, does not necessarily distort the scaffolding architecture and hence does not cause fibrosis, despite loss of hepatocytes. In its initial stages, hepatic fibrosis can regress if the cause is reversible (eg, with viral clearance). After months or years of chronic or repeated injury, fibrosis becomes permanent. Fibrosis develops even more rapidly in mechanical biliary obstruction.
Disorders and Drugs That Can Cause Hepatic Fibrosis. Disorders with direct hepatic effects. Autoimmune hepatitis. Certain storage diseases and inborn errors of metabolism. Alpha- 1 antitrypsin deficiency. Copper storage diseases (eg, Wilson disease)Fructosemia. Galactosemia. Glycogen storage diseases (especially types III, IV, VI, IX, and X)Iron- overload syndromes (hemochromatosis)Lipid abnormalities (eg, Gaucher disease)Peroxisomal disorders (eg, Zellweger syndrome)Tyrosinemia. Congenital hepatic fibrosis. Infections. Bacterial (eg, brucellosis)Parasitic (eg, echinococcosis)Viral (eg, chronic hepatitis B or C*)Nonalcoholic steatohepatitis (NASH)Primary biliary cirrhosis. Primary sclerosing cholangitis. Disorders affecting hepatic blood flow. Budd- Chiari syndrome. Heart failure. Hepatic veno- occlusive disease.
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